HISTOLOGICAL STUDY OF A CORRECTIVE INFLUENCE OF SODIUM 2-((4-AMINO-5-(THIOPHEN-2-YLMETHYL)-4H-1,2,4-TRIAZOL-3-YL)THIO)ACETATE ON THE STATE OF RATS LIVER UNDER CONDITIONS OF ACUTE IMMOBILIZATION STRESS

Objective: The aim of the work was histological study a corrective influence sodium 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl) thio) acetate on state rats liver under conditions acute immobilization stress. Material and Method: As an object research used. All substances were injected intragastrically, daily for 5 days in appropriate doses empty stomach from 9.00-10.00. 1 hour after last injection, 6-hour stress simulated. central part fixed further examination 10% formaldehyde solution, dehydrated alcohols increasing strength, poured into paraffin. Result Discussion: results demonstrate presence stress-protective properties model stress, which reproduced 6 hours. can be seen described presented microscopic picture, test sample to some extent reduced degree damage liver. In terms positive effect condition parenchyma (a more pronounced structural orientation hepatocytes noted, their beam structure contoured, dystrophic changes are less pronounced, round cell infiltrates foci hepatocyte necrosis absent), 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)acetate exhibits We conclude about similarity activity with comparison drug (Mebicar®) at studying histologic